Poster: TMDB.
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Where to watch The Substance
Brazil · changeThe Substance is available with a subscription: Netflix, MUBI, and MUBI Amazon Channel.
Also to rent or buy: Apple TV Store and Amazon Video.
Availability: JustWatch · TMDB. Offers may change.
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On WeWatch
- Not interested or dropped: less than 5% of users
Among participants who allowed statistics. Small samples are omitted. Percentages are rounded down in steps of 5; they do not represent national audiences.
A story for your next watch
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Starring Demi Moore, Margaret Qualley, Dennis Quaid, Edward Hamilton-Clark, Gore Abrams, Oscar Lesage.
Synopsis, genres and cast: TMDB.
Official trailer
YouTube video “Official Trailer #2”, published by the MUBI channel. Video listed by TMDB.
Availability by country
Shortcuts open the service or its search page. See availability links on TMDB.
Catalog checked on 10/27/2026.
Similar titles on WeWatch lists
Posters: TMDB.
Credits
Synopsis, images and ratings: TMDB. This product uses the TMDB API but is not endorsed or certified by TMDB.
This website uses TMDB and the TMDB APIs but is not endorsed, certified, or otherwise approved by TMDB.